Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data

Abstract Background Abnormal DNA methylation is thought to contribute to the onset and progression of systemic sclerosis. Currently, the most comprehensive assay for profiling DNA methylation is whole-genome bisulfite sequencing (WGBS), but its precision depends on read depth and it may be subject t...

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Autores principales:	Jeffrey C. Y. Yu, Yixiao Zeng, Kaiqiong Zhao, Tianyuan Lu, Kathleen Oros Klein, Inés Colmegna, Maximilien Lora, Sahir R. Bhatnagar, Andrew Leask, Celia M. T. Greenwood, Marie Hudson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-06-01
Colección:	Clinical Epigenetics
Materias:	Scleroderma Systemic sclerosis DNA methylation Whole genome bisulfite sequencing Differentially methylated regions Smoothing
Acceso en línea:	https://doi.org/10.1186/s13148-023-01513-w
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