Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data

Abstract Background Abnormal DNA methylation is thought to contribute to the onset and progression of systemic sclerosis. Currently, the most comprehensive assay for profiling DNA methylation is whole-genome bisulfite sequencing (WGBS), but its precision depends on read depth and it may be subject t...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Jeffrey C. Y. Yu, Yixiao Zeng, Kaiqiong Zhao, Tianyuan Lu, Kathleen Oros Klein, Inés Colmegna, Maximilien Lora, Sahir R. Bhatnagar, Andrew Leask, Celia M. T. Greenwood, Marie Hudson
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2023-06-01
Rangatū:	Clinical Epigenetics
Ngā marau:	Scleroderma Systemic sclerosis DNA methylation Whole genome bisulfite sequencing Differentially methylated regions Smoothing
Urunga tuihono:	https://doi.org/10.1186/s13148-023-01513-w
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!