The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells

Retinoids are essential in balancing proliferation, differentiation and apoptosis, and they exert their effects through retinoic acid receptors (RARs) and retinoid X receptors (RXRs). RARβ is a tumor-suppressor gene silenced by epigenetic mechanisms such as DNA methylation in breast, cervical and no...

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Ngā kaituhi matua:	Nisha Rani Dahiya, Boris A. Leibovitch, Rama Kadamb, Nidhi Bansal, Samuel Waxman
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2022-03-01
Rangatū:	Cells
Ngā marau:	breast cancer E-box HDAC: histone deacetylases MAD1: MAX dimerization protein NCoR: nuclear receptor corepressor 1 PAH: paired amphipathic domains
Urunga tuihono:	https://www.mdpi.com/2073-4409/11/7/1179
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!