A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma

Summary: CD147 has emerged as a promising tumor-specific therapeutic target. Identifying small-molecule inhibitors that promote its proteolysis represents a critical step toward advancing clinical translation, while elucidating its mechanisms of action could further accelerate this process. In this...

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Autors principals:	Jiaqi Li, Chaozhe Ma, Pei Cao, Weihua Guo, Pengyu Wang, Yang Yang, Bowen Ding, Fengyi Yin, Zhe Li, Yifei Wang, Shouyi Li, Chongbiao Huang, Xiuchao Wang, Tianxing Zhou, Antao Chang, Liang Zhao, Song Gao, Tiansuo Zhao, Hongwei Wang, Jun Yu, Jingyuan Xu, Yukuan Feng, Jihui Hao
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-08-01
Col·lecció:	Cell Reports Medicine
Matèries:	pancreatic ductal adenocarcinoma gemcitabine dracorhodin CD147 ferroptosis H3K9la
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666379125003659
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