A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma

Summary: CD147 has emerged as a promising tumor-specific therapeutic target. Identifying small-molecule inhibitors that promote its proteolysis represents a critical step toward advancing clinical translation, while elucidating its mechanisms of action could further accelerate this process. In this...

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Principais autores:	Jiaqi Li, Chaozhe Ma, Pei Cao, Weihua Guo, Pengyu Wang, Yang Yang, Bowen Ding, Fengyi Yin, Zhe Li, Yifei Wang, Shouyi Li, Chongbiao Huang, Xiuchao Wang, Tianxing Zhou, Antao Chang, Liang Zhao, Song Gao, Tiansuo Zhao, Hongwei Wang, Jun Yu, Jingyuan Xu, Yukuan Feng, Jihui Hao
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-08-01
Series:	Cell Reports Medicine
Assuntos:	pancreatic ductal adenocarcinoma gemcitabine dracorhodin CD147 ferroptosis H3K9la
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2666379125003659
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