Dissecting the MAPK signaling landscape in malignant melanoma: from BRAF and NRAS mutations to precision combination therapies
Malignant melanoma is an aggressive skin malignancy with a complex molecular landscape and limited treatment durability in advanced stages. Aberrations in the MAPK pathway—most notably BRAF and NRAS mutations—have catalyzed the development of targeted therapies, particularly BRAF/MEK inhibitors, whi...
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| Principais autores: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2026-01-01
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| Serija: | Frontiers in Cell and Developmental Biology |
| Teme: | |
| Online dostop: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1723066/full |
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