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Dissecting the MAPK signaling landscape in malignant melanoma: from BRAF and NRAS mutations to precision combination therapies

Malignant melanoma is an aggressive skin malignancy with a complex molecular landscape and limited treatment durability in advanced stages. Aberrations in the MAPK pathway—most notably BRAF and NRAS mutations—have catalyzed the development of targeted therapies, particularly BRAF/MEK inhibitors, whi...

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Main Authors: Xiaobo Fang, Shuangyin Wang, Shuangxing Fu
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
BRAF inhibitors
combination therapy
MAPK pathway
melanoma
NRAS mutations
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1723066/full
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