Dietary targeting of TRPM8 rewires macrophage immunometabolism reducing colitis severity

Abstract The interplay between diet, host genetics, microbiota, and immune system has a key role in the pathogenesis of inflammatory bowel disease (IBD). Although the causal pathophysiological mechanisms remain unknown, numerous dietary nutrients have been shown to regulate gut mucosal immune functi...

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Hauptverfasser:	D. Cicia, F. Biscu, FA. Iannotti, M. Miraglia, C. Ferrante, N. Iaccarino, S. Cadenas de Miguel, A. Chiavaroli, A. Schiano Moriello, P. De Cicco, MF. Nanì, L. Zanoletti, B-J. Ke, L. van Baarle, K. Talavera, A. Randazzo, I. Elia, R. Capasso, G. Matteoli, E. Pagano, AA. Izzo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2025-04-01
Schriftenreihe:	Cell Death and Disease
Online-Zugang:	https://doi.org/10.1038/s41419-025-07553-9
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