Immunometabolic reprogramming in lung cancer: interplay between immune and stem-like cells in immune checkpoint inhibitor resistance

Abstract Lung cancer remains the leading cause of cancer-related death worldwide. Despite the success of immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1 pathways, a significant number of patients exhibit either primary resistance or acquire resistance over time. While ge...

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Bibliografische Detailangaben

Hauptverfasser:	Ji-Yong Sung, Eui Tae Kim
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-10-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Immunometabolism Cancer stem-like cells (CSCs) Immune checkpoint inhibitor (ICI) resistance Tumor microenvironment (TME) Metabolic reprogramming Metabolic plasticity
Online-Zugang:	https://doi.org/10.1186/s12967-025-07244-1
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