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Improvement of developmental competence of cloned male pig embryos by short hairpin ribonucleic acid (shRNA) vector-based but not small interfering RNA (siRNA)-mediated RNA interference (RNAi) of Xist expression

Xist is an X-linked ribonucleic acid (RNA) gene responsible for the cis induction of X chromosome inactivation (XCI). In cloned mammalian embryos, Xist is ectopically activated at the morula to blastocyst stage on the X chromosome that is supposed to be active, thus resulting in abnormal XCI. Suppre...

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Hlavní autoři: Xuqiong YANG, Xiao WU, Yang YANG, Ting GU, Linjun HONG, Enqin ZHENG, Zheng XU, Fang ZENG, Junsong SHI, Rong ZHOU, Gengyuan CAI, Zhenfang WU, Zicong LI
Médium: Artigo
Jazyk:Inglês
Vydáno: The Society for Reproduction and Development 2019-10-01
Edice:The Journal of Reproduction and Development
Témata:
cloned
pig
ribonucleic acid interference (rnai)
somatic cell nuclear transfer (scnt)
xist
On-line přístup:https://www.jstage.jst.go.jp/article/jrd/65/6/65_2019-070/_pdf/-char/en
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