Improvement of developmental competence of cloned male pig embryos by short hairpin ribonucleic acid (shRNA) vector-based but not small interfering RNA (siRNA)-mediated RNA interference (RNAi) of Xist expression

Xist is an X-linked ribonucleic acid (RNA) gene responsible for the cis induction of X chromosome inactivation (XCI). In cloned mammalian embryos, Xist is ectopically activated at the morula to blastocyst stage on the X chromosome that is supposed to be active, thus resulting in abnormal XCI. Suppre...

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Detalhes bibliográficos

Principais autores:	Xuqiong YANG, Xiao WU, Yang YANG, Ting GU, Linjun HONG, Enqin ZHENG, Zheng XU, Fang ZENG, Junsong SHI, Rong ZHOU, Gengyuan CAI, Zhenfang WU, Zicong LI
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Society for Reproduction and Development 2019-10-01
coleção:	The Journal of Reproduction and Development
Assuntos:	cloned pig ribonucleic acid interference (rnai) somatic cell nuclear transfer (scnt) xist
Acesso em linha:	https://www.jstage.jst.go.jp/article/jrd/65/6/65_2019-070/_pdf/-char/en
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