TNF-alpha-induced cPLA2 expression via NADPH oxidase/reactive oxygen species-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells

Tumor necrosis factor-alpha (TNF-alpha) triggers activation of cytosolic phospholipase A2 (cPLA2) and then enhancing the synthesis of prostaglandin (PG) in inflammatory diseases. However, the detailed mechanisms of TNF-alpha induced cPLA2 expression were not fully defined in human pulmonary alveolar...

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Principais autores:	Chih-Chung Lin, Wei Ning Lin, Rou-Ling Cho, Chen-yu Wang, Li-Der Hsiao, Chuen-Mao Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2016-11-01
Colecção:	Frontiers in Pharmacology
Assuntos:	Cytokines lung inflammation signaling transduction cytosolic phospholipase A2 ASK1
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00447/full
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