Sphingosine 1-Phosphate Induces Cyclooxygenase-2/Prostaglandin E2 Expression via PKCα-dependent Mitogen-Activated Protein Kinases and NF-κB Cascade in Human Cardiac Fibroblasts

In the regions of tissue injuries and inflammatory diseases, sphingosine 1-phosphate (S1P), a proinflammatory mediator, is increased. S1P may induce the upregulation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) system in various types of cells to exacerbate heart inflammation. However, the de...

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Автори:	Chien-Chung Yang, Li-Der Hsiao, Mei-Hsiu Su, Chuen-Mao Yang
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2020-10-01
Серія:	Frontiers in Pharmacology
Предмети:	human cardiac fibroblasts NF-κB mitogen-activated protein kinases PKCα cyclooxygenase-2 sphingosine 1-phosphate
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fphar.2020.569802/full
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