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Tribbles Pseudokinase 3 Converts Sorafenib Therapy to Neutrophil‐Mediated Lung Metastasis in Hepatocellular Carcinoma

Abstract Rapid development of resistance to sorafenib and subsequent hyperprogression in patients with advanced hepatocellular carcinoma (HCC) pose significant challenges, with the underlying mechanisms still largely unknown. Herein, sorafenib‐induced TRIB3 is identified as a liver‐specific determin...

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Principais autores: Xu‐Yan Wang, Yuan Liao, Rui‐Qi Wang, Yi‐Tong Lu, Ying‐Zhe Wang, Yu‐Qi Xin, Dong‐Ming Kuang, Xiang‐Ming Lao, Junying Xu, Zhi‐Ling Zhou, Kunhua Hu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-04-01
Serier:Advanced Science
Fag:
hepatocellular carcinoma
lung metastasis
neutrophil
sorafenib resistance
TRIB3
Online adgang:https://doi.org/10.1002/advs.202413682
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