BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model

Abstract Background Preclinical studies have indicated that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential. However, its effects and molecular mechanisms remain unclear. In this work, we exam...

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Detalhes bibliográficos

Principais autores:	Lingsha Ju, Jiaojiao Yang, Tingting Zhu, Panmiao Liu, Jianjun Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-03-01
Colecção:	BMC Psychiatry
Assuntos:	(2R,6R)-hydroxynorketamine Antidepressant Brain-derived neurotrophic factor Narp Hippocampus
Acesso em linha:	https://doi.org/10.1186/s12888-022-03838-x
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