BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model
Abstract Background Preclinical studies have indicated that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential. However, its effects and molecular mechanisms remain unclear. In this work, we exam...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BMC
2022-03-01
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| Seria: | BMC Psychiatry |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1186/s12888-022-03838-x |
| Etykiety: |
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