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Targeting SARS-CoV-2 programmed −1 ribosomal frameshifting: structural dynamics and RNA-directed antiviral strategies

ABSTRACT Programmed −1 ribosomal frameshifting (−1 PRF) is a translational recoding mechanism used by many RNA viruses to regulate the expression of viral replication proteins. In coronaviruses, including SARS-CoV-2, −1 PRF is controlled by a conserved frameshift stimulation element containing a thr...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Neha Jeena, Inshad Ali Khan
Hōputu: Artigo
Reo:Inglês
I whakaputaina: ASM 2026-09-01
Rangatū:Antimicrobial Agents and Chemotherapy
Ngā marau:
Urunga tuihono:https://journals.asm.org/doi/10.1128/aac.00687-26
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