Human proximal tubular epithelial cell-derived small extracellular vesicles mediate synchronized tubular ferroptosis in hypoxic kidney injury

Hypoxia is the key pathobiological trigger of tubular oxidative stress and cell death that drives the transition of acute kidney injury (AKI) to chronic kidney disease (CKD). The mitochondrial-rich proximal tubular epithelial cells (PTEC) are uniquely sensitive to hypoxia and thus, are pivotal in pr...

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Autors principals:	Xiangju Wang, Chang Seong Kim, Benjamin C. Adams, Ray Wilkinson, Michelle M. Hill, Alok K. Shah, Ahmed Mohamed, Mriga Dutt, Monica S.Y. Ng, Jacobus P.J. Ungerer, Helen G. Healy, Andrew J. Kassianos
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-04-01
Col·lecció:	Redox Biology
Matèries:	Hypoxia Proximal tubular epithelial cells Small extracellular vesicles Lipid peroxidation Ferroptosis AKI-to-CKD transition
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2213231724000181
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