Human proximal tubular epithelial cell-derived small extracellular vesicles mediate synchronized tubular ferroptosis in hypoxic kidney injury

Hypoxia is the key pathobiological trigger of tubular oxidative stress and cell death that drives the transition of acute kidney injury (AKI) to chronic kidney disease (CKD). The mitochondrial-rich proximal tubular epithelial cells (PTEC) are uniquely sensitive to hypoxia and thus, are pivotal in pr...

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Xehetasun bibliografikoak

Egile Nagusiak:	Xiangju Wang, Chang Seong Kim, Benjamin C. Adams, Ray Wilkinson, Michelle M. Hill, Alok K. Shah, Ahmed Mohamed, Mriga Dutt, Monica S.Y. Ng, Jacobus P.J. Ungerer, Helen G. Healy, Andrew J. Kassianos
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2024-04-01
Saila:	Redox Biology
Gaiak:	Hypoxia Proximal tubular epithelial cells Small extracellular vesicles Lipid peroxidation Ferroptosis AKI-to-CKD transition
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2213231724000181
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