Repurposing Based Identification of Novel Inhibitors against MmpS5-MmpL5 Efflux Pump of <i>Mycobacterium smegmatis</i>: A Combined In Silico and In Vitro Study

In the current era of a pandemic, infections of COVID-19 and Tuberculosis (TB) enhance the detrimental effects of both diseases in suffering individuals. The resistance mechanisms evolving in <i>Mycobacterium tuberculosis</i> are limiting the efficiency of current therapeutic measures and pressurizi...

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Auteurs principaux:	Mohd Shahbaaz, Dmitry A. Maslov, Aleksey A. Vatlin, Valery N. Danilenko, Maria Grishina, Alan Christoffels
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-01-01
Collection:	Biomedicines
Sujets:	tuberculosis MmpS5-MmpL5 efflux pumps drug resistance virtual screening QSAR molecular dynamics simulations
Accès en ligne:	https://www.mdpi.com/2227-9059/10/2/333
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