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Adenovirus DNA Polymerase Loses Fidelity on a Stretch of Eleven Homocytidines during Pre-GMP Vaccine Preparation

In this study, we invented and construct novel candidate HIV-1 vaccines. Through genetic and protein engineering, we unknowingly constructed an HIV-1-derived transgene with a homopolymeric run of 11 cytidines, which was inserted into an adenovirus vaccine vector. Here, we describe the virus rescue,...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Zara Hannoun, Edmund G. Wee, Alison Crook, Stefano Colloca, Stefania Di Marco, Tomáš Hanke
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-06-01
Schriftenreihe:Vaccines
Schlagworte:
adenovirus DNA polymerase
T7 polymerase
polymerase fidelity
protein engineering
vaccines
HIVconsvX
Online-Zugang:https://www.mdpi.com/2076-393X/10/6/960
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