Adenovirus DNA Polymerase Loses Fidelity on a Stretch of Eleven Homocytidines during Pre-GMP Vaccine Preparation

In this study, we invented and construct novel candidate HIV-1 vaccines. Through genetic and protein engineering, we unknowingly constructed an HIV-1-derived transgene with a homopolymeric run of 11 cytidines, which was inserted into an adenovirus vaccine vector. Here, we describe the virus rescue,...

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Hlavní autoři:	Zara Hannoun, Edmund G. Wee, Alison Crook, Stefano Colloca, Stefania Di Marco, Tomáš Hanke
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-06-01
Edice:	Vaccines
Témata:	adenovirus DNA polymerase T7 polymerase polymerase fidelity protein engineering vaccines HIVconsvX
On-line přístup:	https://www.mdpi.com/2076-393X/10/6/960
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