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A Prediction of Drug Transport, Distribution, and Absorption Through a Multicompartmental Physiologically Based Pharmacokinetic Model

The objective of this study was to develop a multicompartmental physiologically based pharmacokinetic (PBPK) model that allows for the reproduction of the function of the gastrointestinal system in silico. Based on the typical tools of chemical engineering, transport phenomena, and human physiologic...

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Principais autores: Simone Chiorboli, Antonio D’Ambrosio, Leone Mazzeo, Francesca Santori, Luca Bacco, Federico D’Antoni, Giovanni Palombo, Mario Merone, Vincenzo Piemonte
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-04-01
Serier:Engineering Proceedings
Fag:
PBPK models
compartmental models
pharmacokinetics
gastrointestinal model
Online adgang:https://www.mdpi.com/2673-4591/81/1/13
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