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Advances in Predictions of Oral Bioavailability of Candidate Drugs in Man with New Machine Learning Methodology

Oral bioavailability (F) is an essential determinant for the systemic exposure and dosing regimens of drug candidates. F is determined by numerous processes, and computational predictions of human estimates have so far shown limited results. We describe a new methodology where F in humans is predict...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Urban Fagerholm, Sven Hellberg, Ola Spjuth
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-04-01
Schriftenreihe:Molecules
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Online-Zugang:https://www.mdpi.com/1420-3049/26/9/2572
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