Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates

Abstract Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A inhibitors, but their anti-pathogenic potential has not been comprehensively assessed across eukaryotes. In silico analysis of the subst...

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Hlavní autoři:	Wiebke Obermann, Mohammad Farhan Darin Azri, Leonie Konopka, Nina Schmidt, Francesca Magari, Julian Sherman, Liliana M. R. Silva, Carlos Hermosilla, Andreas H. Ludewig, Hicham Houhou, Simone Haeberlein, Mona Yiting Luo, Irina Häcker, Marc F. Schetelig, Christoph G. Grevelding, Frank C. Schroeder, Gilbert Sei Kung Lau, Anja Taubert, Ana Rodriguez, Andreas Heine, Tiong Chia Yeo, Arnold Grünweller, Gaspar Taroncher-Oldenburg
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-06-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-023-35765-6
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