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Broad-spectrum antiviral activity of the synthetic rocaglate zotatifin against Mayaro virus and other viruses

Viruses pose a significant threat to global public health, yet therapeutic options remain limited. Zotatifin, a synthetic rocaglate targeting eukaryotic initiation factor 4A (eIF4A), inhibits viral protein synthesis and potentially triggers interferon responses; however, its broad-spectrum antiviral...

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Bibliografski detalji
Glavni autori: Patricia Valdés-Torres, Dalkiria Campos, Paola Elaine Galán-Jurado, Dalel Zegarra, Isaac Tuñon-Lorenzo, Félix González-Castillo, María Blanquer, Juan Castillo Mewa, Carmen Rivas, José González-Santamaría
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2026-03-01
Serija:Frontiers in Cellular and Infection Microbiology
Teme:
Online pristup:https://www.frontiersin.org/articles/10.3389/fcimb.2026.1752166/full
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