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Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation

ABSTRACT Human papillomaviruses (HPV) are double-stranded DNA viruses causative in a host of human diseases, including several cancers. Following infection, two viral proteins, E1 and E2, activate viral replication in association with cellular factors and stimulate the DNA damage response (DDR) duri...

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Principais autores: Dipon Das, Molly L. Bristol, Nathan W. Smith, Claire D. James, Xu Wang, Pietro Pichierri, Iain M. Morgan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019-04-01
coleção:mBio
Assuntos:
DNA repair
DNA replication
E1-E2
SIRT1
WRN
cervical cancer
Acesso em linha:https://journals.asm.org/doi/10.1128/mBio.00263-19
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