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Werner Helicase Control of Human Papillomavirus 16 E1-E2 DNA Replication Is Regulated by SIRT1 Deacetylation

ABSTRACT Human papillomaviruses (HPV) are double-stranded DNA viruses causative in a host of human diseases, including several cancers. Following infection, two viral proteins, E1 and E2, activate viral replication in association with cellular factors and stimulate the DNA damage response (DDR) duri...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Dipon Das, Molly L. Bristol, Nathan W. Smith, Claire D. James, Xu Wang, Pietro Pichierri, Iain M. Morgan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019-04-01
Schriftenreihe:mBio
Schlagworte:
DNA repair
DNA replication
E1-E2
SIRT1
WRN
cervical cancer
Online-Zugang:https://journals.asm.org/doi/10.1128/mBio.00263-19
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