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Mindin-mediated αM-integrin endocytosis activates STAT3 to maintain keratinocyte stemness

Abstract Background Keratinocyte stem cells are essential for maintaining epidermal homeostasis and enabling efficient tissue repair. Regulation of their self-renewal and differentiation is critical, as its disruption can impair regeneration and drive pathological conditions such as chronic wounds a...

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Principais autores: Binita Dam, Johan Ajnabi, Tirthankar Saha, Ashish Shrivastava, Krithika Badarinath, Akshay Hegde, Abhik Dutta, Siddham Jasoria, Sunny Kataria, Ashutosh Singh, Colin Jamora
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-06-01
Serier:Cell Communication and Signaling
Fag:
F-Spondin
αMβ2 endocytosis
STAT3 activation
Endosomal acidification
Keratinocyte stemness
Online adgang:https://doi.org/10.1186/s12964-026-02970-5
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