PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer

Protein expression, activation and stability are regulated through inter-connected signal transduction pathways resulting in specific cellular states. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in express...

Description complète

Détails bibliographiques

Auteurs principaux:	Jeanesse Scerri, Christian Scerri, Felix Schäfer-Ruoff, Simon Fink, Markus Templin, Godfrey Grech
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-10-01
Collection:	Frontiers in Endocrinology
Sujets:	acquired resistance breast cancer phospho-profile PKC/MEK/ERK signalosome HER2 positive
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fendo.2022.1010092/full
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!