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Endothelial tPA-dependent recruitment of microglia to vessels protects the blood-brain barrier after stroke

Abstract Background Ischemic stroke is one of the leading causes of death and disability worldwide and thrombolysis, with tissue-type plasminogen activator (tPA) or its mutants, remains the only pharmacological treatment available for the acute phase. In this study, we hypothesised that endothelial...

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Autori principali: Tamara Etuzé, Louis Fosset, Denis Vivien, Benoit Denis Roussel, Eloise Lemarchand
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-03-01
Serie:Fluids and Barriers of the CNS
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Accesso online:https://doi.org/10.1186/s12987-026-00801-w
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