Peroxisome-derived ether lipids regulate lysosomal exocytosis

Abstract Lysosomes and peroxisomes are essential for cellular homeostasis, yet how their activities are coordinated remains poorly understood. Here, we identify peroxisome-derived ether lipids as key regulators of lysosomal function. A genome-wide CRISPR/Cas9 screen in LYSET-deficient mucolipidosis...

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Autors principals:	Liang Chen, Danielle Henn, Zhongzheng Dong, Jiaxuan Liang, Aleksander Wielenga, Goncalo Vale, Bala Burugula, Junyi Zou, Yamuna Krishnan, Jeffrey G McDonald, Jacob Kitzman, Ming Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2026-05-01
Col·lecció:	The EMBO Journal
Accés en línia:	https://doi.org/10.1038/s44318-026-00791-3
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