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Age-dependent antibody profiles to plasmodium antigens are differentially associated with two artemisinin combination therapy outcomes in high transmission setting

The impact of pre-existing immunity on the efficacy of artemisinin combination therapy is largely unknown. We performed in-depth profiling of serological responses in a therapeutic efficacy study [comparing artesunate-mefloquine (ASMQ) and artemether-lumefantrine (AL)] using a proteomic microarray....

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Asıl Yazarlar: Ben Andagalu, Pinyi Lu, Irene Onyango, Elke Bergmann-Leitner, Ruth Wasuna, Geoffrey Odhiambo, Lorna J. Chebon-Bore, Luicer A. Ingasia, Dennis W. Juma, Benjamin Opot, Agnes Cheruiyot, Redemptah Yeda, Charles Okudo, Raphael Okoth, Gladys Chemwor, Joseph Campo, Anders Wallqvist, Hoseah M. Akala, Daniel Ochiel, Bernhards Ogutu, Sidhartha Chaudhury, Edwin Kamau
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2022-10-01
Seri Bilgileri:Frontiers in Medicine
Konular:
artemisinin combination therapy
machine learning
modeling
immunoprofiling
malaria
artesunate-mefloquine
Online Erişim:https://www.frontiersin.org/articles/10.3389/fmed.2022.991807/full
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