Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether–lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya

Artemether–lumefantrine (AL) became the first-line treatment for uncomplicated malaria in Kenya in 2006. Studies have shown AL selects for SNPs in pfcrt and pfmdr1 genes in recurring parasites compared to the baseline infections. The genotypes associated with AL selection are K76 in pfcrt and N86, 1...

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書誌詳細

主要な著者:	Angela O. Achieng, Peninah Muiruri, Luicer A. Ingasia, Benjamin H. Opot, Dennis W. Juma, Redemptah Yeda, Bidii S. Ngalah, Bernhards R. Ogutu, Ben Andagalu, Hoseah M. Akala, Edwin Kamau
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2015-12-01
シリーズ:	International Journal for Parasitology: Drugs and Drug Resistance
主題:	Artemether–lumefantrine Drug-resistance Western Kenya Artemisinin-based combination therapies Africa Chloroquine Molecular markers Genetics
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211320715300014
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