Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19

Abstract The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We determined whether negatively-charged heparin enhanced TMPRSS2 inhibition by alpha-1-antitrypsin (AAT). TMPRSS2 activity was determined in...

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Autori principali:	Xiyuan Bai, Ashley M. Buckle, Eszter K. Vladar, Edward N. Janoff, Reeti Khare, Diane Ordway, David Beckham, Lorelenn B. Fornis, Abraham Majluf-Cruz, Randolph V. Fugit, Brian M. Freed, Soohyun Kim, Robert A. Sandhaus, Edward D. Chan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2022-03-01
Serie:	Scientific Reports
Accesso online:	https://doi.org/10.1038/s41598-022-09133-9
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