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Tramadol enhances PGF2α-stimulated osteoprotegerin synthesis in osteoblasts

Osteoprotegerin (OPG) synthesized by osteoblasts is currently considered a crucial regulator to suppress the formation and function of osteoclasts. We previously showed that the synthesis of OPG is stimulated by prostaglandin F2α (PGF2α) in the involvement of p38 mitogen-activated protein kinase (MA...

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Principais autores: Woo Kim, Kumiko Tanabe, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kazuhiko Fujita, Tetsu Kawabata, Go Sakai, Junko Tachi, Tomoyuki Hioki, Daiki Nakashima, Shinobu Yamaguchi, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Hiroki Iida
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-08-01
coleção:Heliyon
Assuntos:
Tramadol
μ-opioid receptor
PGF2α
Osteoprotegerin
MAP kinase
Osteoblast.
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405844020316224
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