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Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

Abstract Background Although CD4+ memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infection, the depleted nucleotide pool and high dUTP levels in monocyte der...

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Principais autores: Junru Cui, Mesfin Meshesha, Natela Churgulia, Christian Merlo, Edward Fuchs, Jennifer Breakey, Joyce Jones, James T. Stivers
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-09-01
Serier:Retrovirology
Fag:
Human HIV-1 infection
Alveolar macrophage
Monocyte
Replication competent virus
Nucleotide pools
Uracil base excision repair
Online adgang:https://doi.org/10.1186/s12977-022-00607-2
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