Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP

Abstract Background Although CD4+ memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infection, the depleted nucleotide pool and high dUTP levels in monocyte der...

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Үндсэн зохиолчид:	Junru Cui, Mesfin Meshesha, Natela Churgulia, Christian Merlo, Edward Fuchs, Jennifer Breakey, Joyce Jones, James T. Stivers
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2022-09-01
Цуврал:	Retrovirology
Нөхцлүүд:	Human HIV-1 infection Alveolar macrophage Monocyte Replication competent virus Nucleotide pools Uracil base excision repair
Онлайн хандалт:	https://doi.org/10.1186/s12977-022-00607-2
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!