Uncovering the glutamate carboxypeptidase II microenvironment using a multi-labeling proteomic approach

Abstract Glutamate carboxypeptidase II (GCPII) is a membrane-bound metallopeptidase predominantly expressed in neural and prostatic tissues, with significantly elevated levels in prostate carcinoma that increase with tumor grade. Despite its significance as a target for imaging and therapy in prosta...

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Autors principals:	Jana Pokorná, Martin Hadzima, Alena Křenková, Joshua D. Smith, Vladimír Šubr, Robin Kryštůfek, Martin Hubálek, Jana Starková, Karolína Šrámková, Tomáš Etrych, Libor Kostka, František Sedlák, Jan Konvalinka, Pavel Šácha
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	Scientific Reports
Matèries:	PSMA Protein proximity labeling iBody HRP µMap Riboflavin
Accés en línia:	https://doi.org/10.1038/s41598-025-28826-5
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