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Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency.

The mitochondrion is emerging as a key organelle in stem cell biology, acting as a regulator of stem cell pluripotency and differentiation. In this study we sought to understand the effect of mitochondrial complex III inhibition during neuronal differentiation of mouse embryonic stem cells. When exp...

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Detalles Bibliográficos
Principais autores: Sandro L Pereira, Mário Grãos, Ana Sofia Rodrigues, Sandra I Anjo, Rui A Carvalho, Paulo J Oliveira, Ernest Arenas, João Ramalho-Santos
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC3847032?pdf=render
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