Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats

Gabapentinoids are used worldwide as first-line agents for the treatment of neuropathic pain. Accumulating evidence indicates that one of the antihyperalgesic mechanisms of gabapentinoids is through activation of the noradrenergic pathway of the descending pain inhibition system. However, the involv...

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Principais autores:	Harue Yanagimura, Mika Sasaki, Hiroshi Baba, Yoshinori Kamiya
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-05-01
coleção:	Neuroscience Research
Assuntos:	Gabapentin Neuropathic pain Antihyperalgesic effect Descending pain inhibitory system Spinal dorsal horn Serotonin
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0168010223001980
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