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Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats

Gabapentinoids are used worldwide as first-line agents for the treatment of neuropathic pain. Accumulating evidence indicates that one of the antihyperalgesic mechanisms of gabapentinoids is through activation of the noradrenergic pathway of the descending pain inhibition system. However, the involv...

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Wedi'i Gadw mewn:
Prif Awduron: Harue Yanagimura, Mika Sasaki, Hiroshi Baba, Yoshinori Kamiya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2024-05-01
Cyfres:Neuroscience Research
Pynciau:
Gabapentin
Neuropathic pain
Antihyperalgesic effect
Descending pain inhibitory system
Spinal dorsal horn
Serotonin
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S0168010223001980
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