Functional characterization of transcription factor motifs using cross-species comparison across large evolutionary distances.

We address the problem of finding statistically significant associations between cis-regulatory motifs and functional gene sets, in order to understand the biological roles of transcription factors. We develop a computational framework for this task, whose features include a new statistical score fo...

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Autori principali:	Jaebum Kim, Ryan Cunningham, Brian James, Stefan Wyder, Joshua D Gibson, Oliver Niehuis, Evgeny M Zdobnov, Hugh M Robertson, Gene E Robinson, John H Werren, Saurabh Sinha
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2010-01-01
Serie:	PLoS Computational Biology
Accesso online:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000652&type=printable
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