Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus

MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic chimeric antigen receptor (CAR) T cells in their speci...

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Detalhes bibliográficos

Principais autores:	François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-06-01
coleção:	Frontiers in Immunology
Assuntos:	MHC-independent thymic selection MHC restriction tolerance coreceptors
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01216/full
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