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RNA-based co-transfer of human CD8αβ with WT1-specific TCRαβ redirects tumor recognition by CD4 and γδ T-cells towards MHC class I-restricted WT1 epitopes and boosts CD8 T-cell responses with or without CD3 mRNA

Abstract We evaluated the redirection of CD4, γδ and CD8 T-cells towards the Wilms’ tumor protein (WT1) tumor-associated antigen, using a major histocompatibility complex (MHC) class I-restricted WT1-specific T-cell receptor (TCR) introduced via RNA-based engineering. We also studied whether co-tran...

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Principais autores: Diana Campillo-Davo, Donovan Flumens, Zwi N. Berneman, Fumihiro Fujiki, Gils Roex, Maarten Versteven, Heleen H. Van Acker, Viggo F. I. Van Tendeloo, Haruo Sugiyama, Sébastien Anguille, Eva Lion
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-03-01
coleção:Experimental Hematology & Oncology
Assuntos:
T-cell redirection
T-cell receptor
Non-viral engineering
Messenger RNA
T-cell coreceptors
Acesso em linha:https://doi.org/10.1186/s40164-026-00764-6
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