IGF1-mediated mesenchymal-endothelial transition as a potential regulatory target in calcific aortic valve disease

Abstract Background Aortic valve interstitial cells (VICs) are considered a highly plastic heterogeneous mesenchymal cell population. Although previous studies have demonstrated their potential to differentiate into myofibroblasts, osteoblasts, chondrocytes, and adipocytes, their ability to differen...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Binglin Li, Mi Zhou, Jianghong Guo, Tai Kuang, Tao Lyu, Dan Zhu, Xiaoyan Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	BMC Medicine
Assuntos:	Calcific aortic valve disease Mesenchymal-endothelial transition IGF1
Acesso em linha:	https://doi.org/10.1186/s12916-025-04433-z
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!