Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents

Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (IA). This effect is mediated by the interaction between DREAM and KV4 potassium channels and it has...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Diego A. Peraza, Pilar Cercós, Pablo Miaja, Yaiza G. Merinero, Laura Lagartera, Paula G. Socuéllamos, Carolina Izquierdo García, Sara A. Sánchez, Alejandro López-Hurtado, Mercedes Martín-Martínez, Luis A. Olivos-Oré, José R. Naranjo, Antonio R. Artalejo, Marta Gutiérrez-Rodríguez, Carmen Valenzuela
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-02-01
Colecção:	Frontiers in Molecular Neuroscience
Assuntos:	KV4.3 channels DREAM DREAM ligands KChIP A-type current Alzheimer
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fnmol.2019.00011/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!