Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents

Downstream Regulatory Element Antagonist Modulator (DREAM)/KChIP3/calsenilin is a neuronal calcium sensor (NCS) with multiple functions, including the regulation of A-type outward potassium currents (IA). This effect is mediated by the interaction between DREAM and KV4 potassium channels and it has...

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मुख्य लेखकों:	Diego A. Peraza, Pilar Cercós, Pablo Miaja, Yaiza G. Merinero, Laura Lagartera, Paula G. Socuéllamos, Carolina Izquierdo García, Sara A. Sánchez, Alejandro López-Hurtado, Mercedes Martín-Martínez, Luis A. Olivos-Oré, José R. Naranjo, Antonio R. Artalejo, Marta Gutiérrez-Rodríguez, Carmen Valenzuela
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2019-02-01
श्रृंखला:	Frontiers in Molecular Neuroscience
विषय:	KV4.3 channels DREAM DREAM ligands KChIP A-type current Alzheimer
ऑनलाइन पहुंच:	https://www.frontiersin.org/article/10.3389/fnmol.2019.00011/full
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