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Morusin targeting GDF15 enhances ferroptosis and overcomes cisplatin resistance in NSCLC

BackgroundThe natural compound morusin (Mor) acts as a potent tumor suppressor in non-small cell lung cancer (NSCLC), but its potential to sensitize DDP and its direct targets are less understood. This work aims to investigate the DDP-sensitizing effects of Mor and the underlying mechanisms.MethodsC...

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Autori principali: Liang Zhang, Huan Liu, Si Jiang, Desheng Li, Xin Li, Maolei Xu, Jianwen Fei, Ling Zhou
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-06-01
Serie:Frontiers in Pharmacology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2026.1803939/full
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