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Apixaban Enhances Vasodilatation Mediated by Protease-Activated Receptor 2 in Isolated Rat Arteries

Apixaban (APX) is a direct inhibitor of factor X (FXa) approved for prophylaxis and treatment of deep venous thrombosis and atrial fibrillation. Because FXa activates protease-activated receptor 2 (PAR-2) in endothelium and vascular smooth muscle, inhibition of FXa by APX may affect vasomotor functi...

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Autori principali: Ambra Villari, Giovanni Giurdanella, Claudio Bucolo, Filippo Drago, Salvatore Salomone
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017-07-01
Serie:Frontiers in Pharmacology
Soggetti:
apixaban
PAR-2
isolated artery
vasodilatation
endothelium
SLIGRL
Accesso online:http://journal.frontiersin.org/article/10.3389/fphar.2017.00480/full
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